872264-34-1

Basic information

• Product Name: phenyl(quinolin-8-yl)methanol
• Synonyms: phenyl(quinolin-8-yl)methanol
• CAS NO: 872264-34-1
• Molecular Weight: 235.285
• Mol File: 872264-34-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenyl(quinolin-8-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(quinolin-8-yl)methanol(872264-34-1)
• EPA Substance Registry System: phenyl(quinolin-8-yl)methanol(872264-34-1)

Safety Data

• Hazardous Substances Data: 872264-34-1(Hazardous Substances Data)

Upstream product

• 38707-70-9 8-formylquinoline 
• 98-80-6 phenylboronic acid 
• 7496-46-0 8-bromomethyl-quinoline 

Relevant articles and documents

Formation of Tertiary Alcohol via Chelation-Assisted Nickel(II)-Catalyzed Addition of Arylboronic Acids to Unactivated 1-(Quinolin-8-yl)ethan-1-one

The synthesis of tertiary alcohol via chelation-assisted nickel-catalyzed addition of arylboronic acids to unactivated ketones was reported in this study. A series of substituted arylboronic acids was reacted with 1-(quinolin-8-yl)ethan-1-one and its derivatives to provide various substituted 1-aryl-1-(quinolin-8-yl)ethan-1-ols and relevant compounds in medium to good yields. The N-directing group is essential for the addition reaction of arylboronic acids to these unactivated ketones. Nickel(II) acetylacetonate (10.0 mol%) in combination with sodium iodide (2 equiv.) and potassium carbonate (0.8 equiv.) was identified as the optimal catalytic system for the current transformations. (Figure presented.).