87233-54-3

Basic information

• Product Name: 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL)
• Synonyms: 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL);2-CHLORO-1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOLE;2-CHLORO-1-(2-ETHOXYETHYL)-1H-BENZO[D]IMIDAZOLE
• CAS NO: 87233-54-3
• Molecular Formula: C₁₁H₁₃ClN₂O
• Molecular Weight: 224.69
• Mol File: 87233-54-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.612°C at 760 mmHg
• Flash Point: 170.683°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL)(87233-54-3)
• EPA Substance Registry System: 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL)(87233-54-3)

Safety Data

• Hazardous Substances Data: 87233-54-3(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 2-chloro-1-(2-ethoxyethyl) is a chemical compound with the molecular formula C11H13ClN2O and a molecular weight of 218.69 g/mol. It is a white to off-white solid that is used in various industrial applications, including as a building block in the synthesis of pharmaceuticals and agrochemicals. 1H-BENZIMIDAZOLE,2-CHLORO-1-(2-ETHOXYETHYL) is also known to have potential biological activity and is used as a research tool in medicinal chemistry. It is important to handle 1H-Benzimidazole, 2-chloro-1-(2-ethoxyethyl) with care and in accordance with safety guidelines, as it may pose health hazards if not properly managed.

InChI:InChI=1/C11H13ClN2O/c1-2-15-8-7-14-10-6-4-3-5-9(10)13-11(14)12/h3-6H,2,7-8H2,1H3

Upstream product

• 101953-61-1 N-(2-ethoxyethyl)-2-benzimidazolone 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 592-55-2 2-Bromoethyl ethyl ether 
• 4926-55-0 2-[(2-nitrophenyl)amino]ethanol 
• 95893-89-3 N-(β-ethoxyethyl)-o-phenylenediamine 
• 88-73-3 2-Chloronitrobenzene 
• 95893-88-2 N-(β-ethoxyethyl)-o-nitroaniline 
• 628-34-2 2-chloroethyl ethyl ether 
• 95-54-5 1,2-diamino-benzene 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 

Downstream Products

• 87233-61-2 1-methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane 
• 101954-15-8 1-(2-Ethoxy-ethyl)-2-(4-phenyl-piperazin-1-yl)-1H-benzoimidazole 
• 87233-79-2 2-(4-benzyl-1-piperazinyl)-1-(2-ethoxyethyl)benzimidazole 
• 110963-41-2 2-<(1-benzyl-4-piperidinyl)amino>benzimidazole 
• 101954-30-7 2-(4-Benzyl-[1,4]diazepan-1-yl)-1-(2-ethoxy-ethyl)-1H-benzoimidazole 
• 101954-16-9 1-(2-Ethoxy-ethyl)-2-(4-phenethyl-piperazin-1-yl)-1H-benzoimidazole 
• 101954-18-1 2-(4-Benzhydryl-piperazin-1-yl)-1-(2-ethoxy-ethyl)-1H-benzoimidazole 

Relevant articles and documents

Emedastine hydrochloride intermediate compound and preparation method thereof

The invention provides an antihistamine medicine emedastine hydrochloride intermediate and a preparation method thereof, and is used for solving the problems of many reaction steps, operation complexity and high production cost in the preparation process

Synthesis and antihistaminic H1 activity of 1,2,5(6)-trisubstituted benzimidazoles

A number of benzimidazoles, having several substituents on the azole and benzene nuclei and C-2 (methylamino, ethylenediamine, morpholine, piperazine and piperidine) were prepared. Regioselective synthesis was designed for the N1-alkyl substituted benzimidazoles (14-15). X-Ray structure analysis of (14) was also revealed. Compounds were evaluated for their in vitro H1- antihistaminic activity in the isolated guinea-pig ileum method. The compound (11) exhibits best activity.

SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) {1,4}DIAZEPAN-1-YL)-2-(ARYL)BUTYL) BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES

The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula: STR1 stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.