872413-99-5

Basic information

• Product Name: [1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-2-(2,3-dichloro-benzyloxy)-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 872413-99-5
• Molecular Weight: 661.046
• Mol File: 872413-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-2-(2,3-dichloro-benzyloxy)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-2-(2,3-dichloro-benzyloxy)-ethyl]-carbamic acid tert-butyl ester(872413-99-5)
• EPA Substance Registry System: [1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-2-(2,3-dichloro-benzyloxy)-ethyl]-carbamic acid tert-butyl ester(872413-99-5)

Safety Data

• Hazardous Substances Data: 872413-99-5(Hazardous Substances Data)

Upstream product

• 57915-78-3 1-(bromomethyl)-2,3-dichlorobenzene 
• 3262-72-4 (R)-N-tert-butoxycarbonyl serine 
• 416855-48-6 [5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-ylmethyl]ethylamine 
• 616881-97-1 N-tert-butoxycarbonylamino-O-(2,3-dichlorobenzyl)-D-serine 

Downstream Products

• 872414-25-0 2-amino-N-[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-3-(2,3-dichloro-benzyloxy)-N-ethyl-propionamide 

Relevant articles and documents

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.