872460-78-1

Basic information

• Product Name: 3β-(3,4-dichlorophenyl)-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester
• Synonyms: 3β-(3,4-dichlorophenyl)-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester
• CAS NO: 872460-78-1
• Molecular Weight: 487.383
• Mol File: 872460-78-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3β-(3,4-dichlorophenyl)-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-(3,4-dichlorophenyl)-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester(872460-78-1)
• EPA Substance Registry System: 3β-(3,4-dichlorophenyl)-8-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester(872460-78-1)

Safety Data

• Hazardous Substances Data: 872460-78-1(Hazardous Substances Data)

Upstream product

• 143965-99-5 dicholoropane 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 146725-34-0 O-456 

Downstream Products

• 872460-79-2 8-(2-aminoethyl)-3β-(3,4-dichlorophenyl)-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester 

Relevant articles and documents

Rhodamine-labeled 2β-carbomethoxy-3β-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

Novel fluorescent ligands were synthesized to identify a high-affinity probe that would enable visualization of the dopamine transporter (DAT) in living cells. Fluorescent tags were extended from the N- or 2-position of 2β-carbomethoxy-3β-(3,4-dichlorophenyl)tropane, using an ethylamino linker. The resulting 2-substituted (5) and N-substituted (9) rhodamine-labeled ligands provided the highest DAT binding affinities expressed in COS-7 cells (Ki = 27 and 18 nM, respectively) in the series. Visualization of the DAT with 5 and 9 was demonstrated by confocal fluorescence laser scanning microscopy in stably transfected HEK293 cells.