872554-73-9Relevant articles and documents
Solid-phase synthesis of "mixed" peptidomimetics using Fmoc-protected aza-β3-amino acids and α-amino acids
Busnel, Olivier,Bi, Lanrong,Dali, Hayet,Cheguillaume, Arnaud,Chevance, Soizic,Bondon, Arnaud,Muller, Sylviane,Baudy-Floc'h, Michele
, p. 10701 - 10708 (2005)
A solid-phase fluorenylmethyloxycarbonyl (Fmoc)-based synthesis strategy is described for "mixed" aza-β3-peptides as well as a convenient general approach for their required building blocks, the aza-β3-amino acid residues (aza-β3-aa). These monomers allow the synthesis of relatively large quantities of pure mixed aza-β3-peptides. The required Fmoc-substituted aza-β3-amino acids are accessible by convenient synthesis, and a number of monomers including those containing side chains with functional groups have been synthesized. The method was applied toward the solid-phase ynthesis of aza-β3-peptide mimetics of a biologically active histone H4 sequence.
