872619-43-7

Basic information

• Product Name: Methyl 5-bromo-7-azaindole-3-carboxylate
• Synonyms: Methyl 5-bromo-7-azaindole-3-carboxylate;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-, Methyl ester;Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate;5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester
• CAS NO: 872619-43-7
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.06808
• Mol File: 872619-43-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.709±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.33±0.40(Predicted)
• CAS DataBase Reference: Methyl 5-bromo-7-azaindole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-bromo-7-azaindole-3-carboxylate(872619-43-7)
• EPA Substance Registry System: Methyl 5-bromo-7-azaindole-3-carboxylate(872619-43-7)

Safety Data

• Hazardous Substances Data: 872619-43-7(Hazardous Substances Data)

Usage

General Description

Methyl 5-bromo-7-azaindole-3-carboxylate is a chemical compound with the molecular formula C10H8BrN2O2. It is a derivative of the indole family, containing a bromine atom and a methyl ester group. Methyl 5-bromo-7-azaindole-3-carboxylate is commonly used in organic synthesis and medicinal chemistry as a building block for the construction of more complex molecules. Its unique structure and reactivity make it valuable in the development of pharmaceuticals, agrochemicals, and other advanced materials. Methyl 5-bromo-7-azaindole-3-carboxylate is highly sought after for its potential biological activity and is a subject of ongoing research and development.

Upstream product

• 67-56-1 methanol 
• 849068-61-7 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 35486-42-1 2-amino-3,5-dibromopyridine 
• 76-02-8 trifluoroacetyl chloride 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1200130-71-7 1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-72-8 1-benzenesulfonyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-80-8 9-benzenesulfonyl-5-bromo-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-78-4 9-benzenesulfonyl-5-hydroxy-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-79-5 1,1,2,2,3,3,4,4,4-nonafluorobutanesulfonic acid 9-benzenesulfonyl-6-cyano-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrol-5-yl ester 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

PYRROLOPYRIMIDINE ITK INHIBITORS

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID

The present invention relates to new compounds of formula I as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containin