87269-86-1

Basic information

• Product Name: (E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride
• Synonyms: (2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride;(E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride;(2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride(WX112251S1)
• CAS NO: 87269-86-1
• Molecular Formula: C₈H₁₃NO₂*ClH
• Molecular Weight: 191.66
• Mol File: 87269-86-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 155.8 °C
• Appearance: /
• Vapor Pressure: 2.53E-05mmHg at 25°C
• CAS DataBase Reference: (E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride(87269-86-1)
• EPA Substance Registry System: (E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride(87269-86-1)

Safety Data

• Hazardous Substances Data: 87269-86-1(Hazardous Substances Data)

Usage

General Description

(E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride is a chemical compound that is used in the synthesis of pharmaceutical drugs and as a building block in organic chemistry. (E)-(-)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride is a derivative of cyclopentane and contains a carboxylic acid group, making it an important intermediate in the production of various drugs and pharmaceuticals. It is also used as a chiral building block in the synthesis of complex molecules with specific stereochemistry. In addition, this compound has been studied for its potential biological activity and therapeutic applications, making it a valuable tool for pharmaceutical research and development.

InChI:InChI=1/C8H13NO2.ClH/c10-8(11)7-4-5-2-1-3-6(5)9-7;/h5-7,9H,1-4H2,(H,10,11);1H

Upstream product

• 93661-93-9 2,3,3a,4,5,6-Hexahydro-cyclopenta[b]pyrrole-2-carboxylic acid; hydrochloride 
• 97475-97-3 ethyl octahydrocyclopenta[b]pyrrole-2-carboxylate 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 87269-85-0 (±)-methyl 2-(acetylamino)-3-(2-oxocyclopentyl)-propionate 
• 2611-03-2 2-chlorocyclopent-1-ene-1-carbaldehyde 
• 97475-96-2 ethyl 1-Benzyl-1,4,5,6-Tetrahydrocyclopenta[b]Pyrrole-2-Carboxylate 
• 87269-87-2 cis,endo-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester hydrochloride 
• 87269-87-2 benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride 

Downstream Products

• 87269-87-2 (1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeurebenzylester-hydrochlorid 
• 87269-87-2 cis,endo-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester hydrochloride 
• 93779-32-9 (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid; compound with (2S,3aS,6aS)-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester 
• 109428-53-7 (2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 133696-29-4 (1R,5R)-2-(1-Cyclohexen-1-yl)-2-azabicyclo<3.3.0>octan 
• 133616-95-2 (1RS,5RS,3'R)-2-Carbamoyl-(3'-methylphenyl)-2-azabicyclo<3.3.0>octan 
• 124002-32-0 (2S,3aS,6aS)-1-[(tert-butoxy)carbonyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 
• 129939-63-5 ramipril 
• 87333-19-5 Ramipril 
• 87269-88-3 2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester 
• 87269-87-2 benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride 
• 130309-34-1 (2S,3aS,6aS)-1-{[(9H-Fluoren-9-yl)methoxy]carbonyl}octahydrocyclopenta[b]pyrrole-2-carboxylic acid 

Relevant articles and documents

MASP INHIBITORY COMPOUNDS AND USES THEREOF

The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

IMPROVED RAMIPRIL SYNTHESIS

The present invention relates to the preparation of ramipril (formula [1]) from unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid and to a method for preparing unprotected (2S,3S,6S)-octahydrocyclopenta[b]pyrrole-2- carboxylic acid.

SYNTHESIS OF UNNATURAL AMINO ACIDS: (S,S,S)-2-AZABICYCLOOCTANE-3-CARBOXYLIC ACID

(S,S,S)-2-Azabicyclooctane-3-carboxylic acid 1, a structural element of the very potent ACE inhibitor HOE 498, is readily available via a diastereo selective synthesis starting from serine or cystine.