872692-21-2

Basic information

• Product Name: Piperidine, 1-[(2S)-2-amino-3-methyl-1-oxobutyl]-4-(phenylmethoxy)-
• CAS NO: 872692-21-2
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Mol File: 872692-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[(2S)-2-amino-3-methyl-1-oxobutyl]-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(2S)-2-amino-3-methyl-1-oxobutyl]-4-(phenylmethoxy)-(872692-21-2)
• EPA Substance Registry System: Piperidine, 1-[(2S)-2-amino-3-methyl-1-oxobutyl]-4-(phenylmethoxy)-(872692-21-2)

Safety Data

• Hazardous Substances Data: 872692-21-2(Hazardous Substances Data)

Upstream product

• 872692-35-8 N-tert-butoxycarbonyl-L-valine 4-benzyloxypiperidide 
• 159557-47-8 4-benzyloxypiperidine-1-carboxylic acid tert-butyl ester 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 13734-41-3 t-Boc-L-valine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 76716-51-3 4-(benzyloxy)piperidine 

Downstream Products

• 872692-22-3 N-(2-ethoxycarbonyl)-L-valine 4-(benzyloxy)piperidide 

Relevant articles and documents

Asymmetric michael reactions on polymeric support: Auxiliary immobilization and stereoselective construction of quaternary stereocenters

Several strategies for the immobilization of a L-valine-derived auxiliary on a Merrifield resin and on poly(ethylene glycol) are reported. The latter is shown to work excellently in asymmetric copper(II)-catalyzed Michael reactions of cyclic β-oxo esters 2 with methyl vinyl ketone (4), yielding the corresponding addition products 5 with quaternary stereocenter in selectivities of 97-99 % ee. The PEG-supported auxiliary 1d can be precipitated from diethyl ether solutions and reused. A sulfur-containing β-oxo ester 2c was prepared in 92 % yield by a DMAP-catalyzed transesterification method in order to detect enamine formation on solid support. The sulfur content can be used as an additional parameter in combustion analysis and therefore, may act as a diagnostic probe for enamine formation. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.