872729-81-2Relevant articles and documents
New renin inhibitors containing pseudodipeptidic units in P 3-P2 and P1-P1′ positions
Paruszewski, Ryszard,Jaworski, Pawel,Bodnar, Magdalena,Dudkiewicz-Wilczynska, Jadwiga,Roman, Iza
, p. 1305 - 1309 (2007/10/03)
A series of four non-peptidic renin inhibitors have been designed and synthesized. All of them contain in their molecule (3S,4S)-4-amino-5-cyclohexyl- 3-hydroxypentanoic acid (ACHPA), a hydrophobic portion at the C-terminus and a second dipeptide-like tra