872996-05-9

Basic information

• Product Name: (S)-tomoxetine (S)-(+)-mandelate
• Synonyms: (S)-tomoxetine (S)-(+)-mandelate
• CAS NO: 872996-05-9
• Molecular Weight: 407.51
• Mol File: 872996-05-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-tomoxetine (S)-(+)-mandelate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tomoxetine (S)-(+)-mandelate(872996-05-9)
• EPA Substance Registry System: (S)-tomoxetine (S)-(+)-mandelate(872996-05-9)

Safety Data

• Hazardous Substances Data: 872996-05-9(Hazardous Substances Data)

Usage

Description

(S)-Tomoxetine (S)-(+)-mandelate is a chemical compound that serves as a selective norepinephrine reuptake inhibitor (SNRI). It is the active ingredient in the prescription medication Strattera, designed to enhance the bioavailability and stability of tomoxetine, making it a more effective treatment option for attention deficit hyperactivity disorder (ADHD).

Uses

Used in Pharmaceutical Industry:
(S)-Tomoxetine (S)-(+)-mandelate is used as a therapeutic agent for the treatment of attention deficit hyperactivity disorder (ADHD). It functions by increasing the levels of norepinephrine in the brain, which aids in improving focus, attention, and impulse control in individuals diagnosed with ADHD. The (S)-(+)-mandelate form specifically enhances the compound's bioavailability and stability, providing a more reliable treatment option.

Upstream product

• 42142-52-9 3-methylamino-1-phenylpropan-1-ol 
• 95-52-3 2-Fluorotoluene 
• 17199-29-0 (S)-Mandelic acid 
• 107674-34-0 tomoxetine oxalic acid salt 
• 63940-51-2 (+/-)-atomoxetine 

Downstream Products

• 82248-59-7 atomoxetine hydrochloride 

Relevant articles and documents

Preparation method of atomoxetine hydrochloride

The invention relates to the field of medicine chemistry, and provides a preparation method of atomoxetine hydrochloride. N-methyl-3-hydroxyl-benzedrine is used as an initial raw material to take an aromatic nucleophilic substitution with o-fluorotoluene; then, through (S)-racemic ethyl mandelate resolution, salt is obtained, and the atomoxetine hydrochloride is obtained. In the route, the multistep reaction uses the continuous operation; reaction post treatment extraction and chiral resolution salt forming solvents use methyl tertiary butyl ether; during the post treatment, reduced pressure concentration operation and anhydrous sodium sulfate drying steps are not used; the operation is simple; the total yield reaches 20 to 25 percent; the purity is 99.5 percent or higher; the relevant quality standard is met. The process does not have the special reaction parameter and equipment requirements; the yield is high; byproducts are few; the post treatment is simple; the reaction yield is high; the method is suitable for industrialized production.

AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.