873331-73-8Relevant articles and documents
Preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine
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Paragraph 0021; 0022, (2017/10/31)
The invention discloses a preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine. A target product is obtained by taking 2-ethyl pyrimidine as a starting raw material through bromine feeding, coupling, elimination and catalytic hydrogenation reaction. The compound is an important medicine intermediate.
SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
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Paragraph 1283-1284, (2015/02/25)
Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.
TREATMENT OF CANCERS HAVING K-RAS MUTATIONS
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Page/Page column 178, (2011/11/01)
The present invention provides a method of treating a cancer associated with a K- ras mutation in a subject in need thereof. The method comprises the steps of (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) adminsiterign to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.