87357-67-3Relevant articles and documents
BIFUNCTIONAL COMPOUND AND ITS USE IN IMMUNOTHERAPY
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, (2021/02/12)
The invention relates to a bifunctional compound that is, on one side, an agonist of the TLR4 and, on the other side, an important inhibitor of the PSMA. Said compound is useful in immunotherapy for the treatment and/or prevention of prostate cancer. Therefore, the invention also relates to the use of the compound and to the pharmaceutical composition comprising it.
SYNTHETIC DERIVATIVES OF MPL AND USES THEREOF
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, (2014/11/13)
In one aspect, the present disclosure provides compounds of formulae (I) and (II). In another aspect, a compound of formula (I) or (II) is formulated into compositions with an antigen, optionally with a vesicle. In some embodiments, compositions are administered intramuscularly.
Preparation of a lipid A derivative that contains a 27-hydroxyoctacosanoic acid moiety
Santhanam, Balaji,Boons, Geert-Jan
, p. 3333 - 3336 (2007/10/03)
(Chemical Equation Presented) A general synthetic strategy for long-chain ω-1 hydroxy fatty acids has been developed, which employs as a key reaction step a cross metathesis between ω-unsaturated ester and 3-butene-2-ol. The resulting lipids were used for