873913-87-2 Usage
General Description
6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine, also known as CDP, is a chemical compound with the molecular formula C20H13ClN4. It is a heterocyclic aromatic compound that contains a chlorine atom and two phenyl groups attached to an imidazopyridazine ring system. CDP is a potent and selective inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP), which is involved in DNA repair processes. Due to its PARP inhibitory activity, CDP has shown potential therapeutic effects in cancer treatment, particularly in combination with DNA-damaging agents such as chemotherapy and radiation therapy. Research on CDP and its derivatives continues to explore its potential applications in cancer therapy and other disease treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 873913-87-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,9,1 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 873913-87:
(8*8)+(7*7)+(6*3)+(5*9)+(4*1)+(3*3)+(2*8)+(1*7)=212
212 % 10 = 2
So 873913-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H12ClN3/c19-15-11-12-16-20-17(13-7-3-1-4-8-13)18(22(16)21-15)14-9-5-2-6-10-14/h1-12H
873913-87-2Relevant articles and documents
Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr
El Akkaoui,Koubachi,El Kazzouli,Berteina-Raboin,Mouaddib,Guillaumet
, p. 2472 - 2475 (2008/09/20)
The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and ar
New calcineurin inhibiting 3-dimethylaminopropyl substituted diarylheterocycles by sonogashira reactions and catalytic hydrogenation
Yin, Lunxiang,Erdmann, Frank,Liebscher, Juergen
, p. 1369 - 1379 (2007/10/03)
A series of calcineurin inhibiting compounds 1 consisting of a central aromatic N-heterocycle, two aryl substituents and a 3-dimethylaminopropyl chain was synthesized by introduction of the side chain. A corresponding haloheterocycle 3 was transformed int
