873925-63-4Relevant articles and documents
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex - Part 2
Kohrt, Jeffrey T.,Filipski, Kevin J.,Cody, Wayne L.,Cai, Cuiman,Dudley, Danette A.,Van Huis, Chad A.,Willardsen, J. Adam,Narasimhan, Lakshmi S.,Zhang, Erli,Rapundalo, Stephen T.,Saiya-Cork, Kamlai,Leadley, Robert J.,Edmunds, Jeremy J.
, p. 1060 - 1064 (2007/10/03)
The activated factor VII/tissue factor complex (FVIIa/TF) is known to play a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered whi
