87394-63-6

Basic information

• Product Name: 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE
• Synonyms: 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE;1-(3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZINE;1-[3-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINE;BUTTPARK 27\08-97;1-[3-(Trifluoromethyl)pyridine-2-yl]piperazine;1-[3-(Trifluoromethyl)-2-pyridyl]piperazine, 95+%;1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine 99%;1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine99%
• CAS NO: 87394-63-6
• Molecular Formula: C₁₀H₁₂F₃N₃
• Molecular Weight: 231.22
• Product Categories: pharmacetical;Heterocyclic Building Blocks
• Mol File: 87394-63-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 45-47°C
• Boiling Point: 106°C 1,5mm
• Flash Point: 146.9 °C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 0.000341mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE(87394-63-6)
• EPA Substance Registry System: 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE(87394-63-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 87394-63-6(Hazardous Substances Data)

Usage

General Description

1-[3-(Trifluoromethyl)pyrid-2-yl]piperazine is a chemical compound with the molecular formula C11H13F3N2. It is a piperazine derivative with a trifluoromethyl group attached to the pyridine ring. 1-[3-(TRIFLUOROMETHYL)PYRID-2-YL]PIPERAZINE is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in the pharmaceutical industry as a building block for the synthesis of new drug candidates. Additionally, the trifluoromethyl group in the molecule can impart unique properties and enhance the biological activity of the resulting compounds. Overall, 1-[3-(Trifluoromethyl)pyrid-2-yl]piperazine is a versatile chemical with potential applications in various fields, particularly in drug discovery and development.

InChI:InChI=1/C10H12F3N3/c11-10(12,13)8-2-1-3-15-9(8)16-6-4-14-5-7-16/h1-3,14H,4-7H2

Upstream product

• 110-85-0 piperazine 
• 65753-52-8 2-fluoro-3-trifluoromethylpyridine 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 584-08-7 potassium carbonate 
• 946399-62-8 tert-butyl 4-(3-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxylate 

Downstream Products

• 833468-70-5 4-(3-chloro-4-fluorophenyl)-6-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-isopropylpyrimidine 
• 833463-04-0 2-chloro-4-(3-chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidine 
• 548768-70-3 4-[3-(Trifluoromethyl)pyridin-2-yl]-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 178974-50-0 1-(8-Aza-bicyclo[3.2.1]oct-8-yl)-2-phenyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butan-1-one 
• 1043475-92-8 C₁₉H₂₂F₃N₃O₂S 
• 1043475-85-9 C₁₈H₂₀F₃N₃O₂S 

Relevant articles and documents

ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES

The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.

COMPOUNDS AS TRVP1 BLOCKERS, PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF

A kind of new compounds, and their pharmaceutically acceptable salts, and hydrates are disclosed. The pharmaceutical composition thereof is also provided. And also are the medical uses of the compounds, pharmaceutically acceptable salts, hydrates and the

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).