87394-65-8

Basic information

• Product Name: 1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE
• Synonyms: CHEMBRDG-BB 4004469;5-CHLORO-2-(PIPERAZIN-1-YL)PYRIDINE;1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE;1-(5-CHLORO-2-PYRIDINYL)PIPERAZINE;1-(5-chloropyridin-2-yl)piperazine(SALTDATA: FREE);Piperazine, 1-(5-chloro-2-pyridinyl)-;1-(5-Chloro-2-pyridinyl)-piperazine 2HCl
• CAS NO: 87394-65-8
• Molecular Formula: C₉H₁₂ClN₃
• Molecular Weight: 197.66
• Product Categories: pharmacetical;Building Blocks;Pyridine
• Mol File: 87394-65-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 351.5°C at 760 mmHg
• Flash Point: 166.4°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 4.08E-05mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE(87394-65-8)
• EPA Substance Registry System: 1-(5-CHLORO-PYRIDIN-2-YL)-PIPERAZINE(87394-65-8)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 87394-65-8(Hazardous Substances Data)

Usage

Uses

1-(5-Chloropyridin-2-yl)piperazine

InChI:InChI=1/C9H12ClN3/c10-8-1-2-9(12-7-8)13-5-3-11-4-6-13/h1-2,7,11H,3-6H2

Upstream product

• 110-85-0 piperazine 
• 16110-09-1 2,5 dichloropyridine 
• 87412-10-0 5-chloro-2-<<(trifluoromethyl)sulfonyl>oxy>pyridine 
• 4214-79-3 5-chloro-2-pyridinol 
• 945422-86-6 tert-butyl 4-(5-chloropyridin-2-yl)piperazine-1-carboxylate 
• 40473-01-6 2-Bromo-5-chloro-pyridine 

Downstream Products

• 401566-32-3 C₂₂H₃₂N₅O₃SCl 
• 223512-06-9 N-(4-((4-(5-Chloropyridin-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide 
• 1219624-30-2 1-{2-[4-(5-chloropyridin-2-yl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one 

Relevant articles and documents

SYA 013 analogs as moderately selective sigma-2 (σ2) ligands: Structure-affinity relationship studies

Several lines of evidence suggest that selective sigma-2 (σ2) ligands might be useful for the treatment of solid tumors. However, very few selective σ2 ligands have been identified. This study was aimed at identifying new selective σ

PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2- yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist

High throughput screening using the recombinant human TRPV1 receptor was used to identify a series of pyridinylpiperazine ureas (3) as TRPV1 vanilloid receptor ligands. Exploration of the structure-activity relationships by parallel synthesis identified t