873960-29-3Relevant articles and documents
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M.,Tasber, Edward S.,Neilson, Lou Anne,Coleman, Paul J.,Fraley, Mark E.,Olson, Christy,Bergman, Jeff,Torrent, Maricel,Buser, Carolyn A.,Rickert, Keith,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Tao, Weikang,South, Vicki J.,Diehl, Ronald E.,Davide, Joseph P.,Yan, Youwei,Kuo, Lawrence C.,Li, Chunze,Prueksaritanont, Thomayant,Fernandez-Metzler, Carmen,Mahan, Elizabeth A.,Slaughter, Donald E.,Salata, Joseph J.,Kohl, Nancy E.,Huber, Hans E.,Hartman, George D.
, p. 5671 - 5676 (2008/04/07)
Observations from two structurally related series of KSP inhibitors led to the proposal and discovery of dihydropyrazolobenzoxazines that possess ideal properties for cancer drug development. The synthesis and characterization of this class of inhibitors
MITOTIC KINESIN INHIBITORS
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Page/Page column 30, (2010/10/20)
The present invention relates to tricyclic pyrazoles according to Formula (III) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also r
