874-17-9

Basic information

• Product Name: 2,6-Dibromo-4-chloroaniline
• Synonyms: 2,6-DIBROMO-4-CHLOROANILINE;4-CHLORO-2,6-DIBROMOANILINE;LABOTEST-BB LT01147813;1-Amino-4-chloro-2,6-dibromobenzene;4-CHLORO-2,6-DIBROMOANILINE, 98+%;2,6-Dibromo-4-chloroaniline, 98+%;4-chloro-4,6-dibromoaniline
• CAS NO: 874-17-9
• Molecular Formula: C₆H₄Br₂ClN
• Molecular Weight: 285.36
• Product Categories: Amines;blocks;Bromides;Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds;Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 874-17-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 94-96 °C(lit.)
• Boiling Point: 301 °C
• Flash Point: 133.7 °C
• Appearance: /
• Density: 2.097 g/cm³
• Vapor Pressure: 0.00135mmHg at 25°C
• Refractive Index: 1.669
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.16±0.10(Predicted)
• BRN: 2803730
• CAS DataBase Reference: 2,6-Dibromo-4-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dibromo-4-chloroaniline(874-17-9)
• EPA Substance Registry System: 2,6-Dibromo-4-chloroaniline(874-17-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39-24/25-22
• WGK Germany: 3
• Hazardous Substances Data: 874-17-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-2,6-dibromoaniline is a symmetrical chlorodibromo aniline. 4-Chloro-2,6-dibromoaniline was prepared by bromination of p-chloroaniline.

InChI:InChI=1/C6H4Br2ClN/c7-4-1-3(9)2-5(8)6(4)10/h1-2H,10H2

Upstream product

• 67-66-3 chloroform 
• 608-30-0 2,6-dibromoaniline 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 147-82-0 2,4,6-tribromoaniline 
• 5608-87-7 5-(4-chloro-anilino)-penta-2,4-dienal-(4-chloro-phenylimine) 
• 106-47-8 4-chloro-aniline 
• 823-86-9 N-(4-chlorophenyl)hydroxylamine 
• 10035-10-6 hydrogen bromide 
• 67-56-1 methanol 
• 7726-95-6 bromine 
• 14030-87-6 2,6-dibromo-4-thiocyanato-aniline 
• 64-19-7 acetic acid 
• 133-74-4 2-amino-5-chlorobenzenesulfonic acid 
• 7732-18-5 water 

Downstream Products

• 71756-95-1 2,6-dibromo-4-chloro-N-nitro-aniline 
• 14862-52-3 1,3-dibromo-5-chlorobenzene 
• 189937-24-4 2,6-Dibromo-4-chloroacetanilide 
• 45860-20-6 2,6-dibromo-4-chloronitrosobenzene 
• 203051-52-9 N-(5'-Chloro-[1,1';3',1'']terphenyl-2'-yl)-S-(2,4-dichloro-phenyl)-thiohydroxylamine 
• 1195791-13-9 C₁₄H₁₁Br₂ClN₂ 
• 1281994-99-7 C₅₆H₃₈Cl₂N₂ 
• 1284224-04-9 N,1-dicyclohexyl-4-bromo-6-chloro-1H-2-aminobenzimidazole 
• 1214890-61-5 C₆H₃Br₃ClN 
• 1423469-24-2 1-(2,6-dibromo-4-chlorophenyl)-1H-pyrrole 
• 1426169-44-9 bis[N,N'-(4-chloro-2,6-diphenylphenyl)imino]acenaphthene 
• 1426169-47-2 {bis[N,N'-(4-chloro-2,6-diphenylphenyl)imino]acenaphthene}dibromonickel 
• 1427000-91-6 4,5,6,7-tetrahydro-3-(2,6-dibromo-4-chlorophenyl)-(3H)-benzothiazole-2-thione 

Relevant articles and documents

A Practical Procedure for Regioselective Bromination of Anilines

A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na 2S 2O 8in the presence of a catalytic amount of CuSO 4·5H 2O enabled regioselective bromination.

NLRP MODULATORS

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Method of catalytically synthesizing polybromo-aniline in water phase

The invention discloses a method of catalytically synthesizing polybromo-aniline in a water phase. The method comprises following steps: adding a catalytic amount of a free radical initiator, aniline derivatives, cheap and low-toxic bromine salts, and water into a reactor; carrying out reactions in a photocatalytic reaction instrument under power of 5W at a room temperature; after a while, extracting the reaction product by ethyl acetate, and carrying out recrystallization to obtain polybromo-aniline; wherein the free radical initiator is eosin, sodium persulfate, or potassium persulfate. The power of the incandescent lamp of the photocatalytic reaction instrument is 5W. The free radical initiator and bromine salts are cheap and easily available. The method is an ideal synthesis method of polybromo-aniline. Cheap and low-toxic bromine salts are used to replace liquid bromine. The cheap and easily available free radical initiator is used to replace unstable and explosive hydrogen peroxide. After 4 to 10 hours of reactions under the power of 5W, polybromo-aniline can be synthesized, the yield and the reaction selectivity are high, the byproducts are few, and the post treatment is simple.