874-77-1

Basic information

• Product Name: 1-(4-METHYLPIPERAZINE)ACETONITRILE
• Synonyms: 4-METHYL-1-PIPERAZINEACETONITRILE;1-(4-METHYLPIPERAZINE)ACETONITRILE;2-(4-methylpiperazin-1-yl)acetonitrile
• CAS NO: 874-77-1
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.2
• Mol File: 874-77-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 230.152 °C at 760 mmHg
• Flash Point: 89.486 °C
• Appearance: /Solid
• Density: 0.998g/cm³
• Vapor Pressure: 0.067mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-METHYLPIPERAZINE)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHYLPIPERAZINE)ACETONITRILE(874-77-1)
• EPA Substance Registry System: 1-(4-METHYLPIPERAZINE)ACETONITRILE(874-77-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 874-77-1(Hazardous Substances Data)

Usage

General Description

1-(4-Methylpiperazine)acetonitrile is a chemical compound with the molecular formula C8H15N3. It is a derivative of piperazine, a heterocyclic amine commonly used in the synthesis of pharmaceuticals and organic compounds. The acetonitrile group in this compound makes it a useful building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as an intermediate in the production of dyes and pigments. Additionally, the presence of the 4-methyl group in the piperazine ring provides this compound with unique chemical properties that make it valuable for a wide range of applications in organic synthesis.

InChI:InChI=1/C7H13N3/c1-9-4-6-10(3-2-8)7-5-9/h3-7H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 143-33-9 sodium cyanide 
• 19212-84-1 1-[(4-methylpiperazin-1-yl)methyl]-1H-1,2,3-benzotriazole 
• 590-17-0 cyanomethyl bromide 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 67886-70-8 2-cyano-6-methoxynaphthalene 
• 74764-51-5 2-(pyridine-2-yl)benzonitrile 
• 54175-73-4 2-(benzo[d]oxazol-2-yl)benzonitrile 
• 76889-76-4 2-(1H-benzo[d]imidazol-2-yl)benzonitrile 
• 650579-66-1 N-hydroxy-2-(4-methylpiperazin-1-yl)ethanimidamide 

Relevant articles and documents

New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity

New analogues of the recently published compound DDD107498 were prepared. Their activities were examined in vitro against the chloroquine-sensitive NF54 strain. The most active were also tested against the multiresistant K1 strain of Plasmodium falciparum. A couple of the newly synthesized compounds showed promising antiplasmodial activity and selectivity. A single compound showed adequate reduction of parasitaemia (98.1%) in mice infected with Plasmodium berghei. Survival time was doubled compared to control. The results of the biological tests of the novel compounds were compared with the activities of drugs in use. Structure-activity relationships were discussed.

PHENYL-UREA AND PHENYL-CARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION

The present invention relates to certain phenyl-urea and phenyl-carbamate derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.

Synthesis, characterization and in vitro biological studies of novel cyano derivatives of N-alkyl and N-aryl piperazine

Cyano derivatives of N-alkyl and N-aryl piperazine have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652) and antifungal activity against pathogenic strains of Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger (ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However, compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity against Aspergillus pathogenic strains. The compounds reported in this study were assessed for there cytotoxicity using MTT colorimetric assay on Hela cells. All the compounds showed cell viability more than the control drug gentamicin, with compound 2 having highest i.e. 95% cell viability.