874208-90-9 Usage
Description
m-PEG7-t-butyl ester is a PEG (polyethylene glycol) linker that incorporates a t-butyl ester group. This molecule features a t-butyl protected carboxyl group, which can be selectively removed under acidic conditions. The hydrophilic PEG spacer within the molecule enhances its solubility in aqueous environments, making it a versatile component in various applications.
Uses
Used in Pharmaceutical Industry:
m-PEG7-t-butyl ester is used as a drug delivery carrier for enhancing the solubility and bioavailability of therapeutic agents. The t-butyl protected carboxyl group allows for pH-sensitive release of the drug, ensuring targeted delivery and reduced side effects.
Used in Bioconjugation:
m-PEG7-t-butyl ester is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The deprotection of the t-butyl ester under acidic conditions enables the formation of stable covalent bonds with target molecules.
Used in Diagnostic Imaging:
m-PEG7-t-butyl ester is used as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT). The hydrophilic PEG spacer improves the solubility and circulation time of the contrast agent in the body, leading to enhanced imaging quality.
Used in Cosmetics and Personal Care:
m-PEG7-t-butyl ester is used as a solubilizing agent in cosmetics and personal care products. Its ability to increase the solubility of hydrophobic ingredients in aqueous formulations helps to create stable, homogeneous products with improved texture and performance.
Used in Material Science:
m-PEG7-t-butyl ester is used in the development of stimuli-responsive materials, such as hydrogels or self-healing polymers. The t-butyl ester group can be deprotected in response to specific environmental triggers, enabling the controlled release of encapsulated substances or the self-healing of damaged materials.
Check Digit Verification of cas no
The CAS Registry Mumber 874208-90-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,2,0 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 874208-90:
(8*8)+(7*7)+(6*4)+(5*2)+(4*0)+(3*8)+(2*9)+(1*0)=189
189 % 10 = 9
So 874208-90-9 is a valid CAS Registry Number.
874208-90-9Relevant articles and documents
PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, USEFUL IN THERAPY, AND THEIR PREPARATION
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Page/Page column 184, (2018/12/02)
The present disclosure relates to compounds of formula (I): RCG1-L-P (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an activated O; and L represents a specific linker. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.
