874279-84-2Relevant articles and documents
Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor
Fjellaksel, Richard,Boomgaren, Marc,Sundset, Rune,Haraldsen, Ira H.,Hansen, J?rn H.,Riss, Patrick J.
, p. 1965 - 1969 (2017)
In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-tert-butylphenyl)-4-piperazinyl-benzimidazole scaffold via Cu-catalysed
Revisiting the Synthesis of 4,6-Difluorobenzofuroxan: A Study of Its Reactivity and Access to Fluorinated Quinoxaline Oxides
Jovené, Cyril,Jacquet, Morgane,Marrot, Jérome,Bourdreux, Flavien,Kletsky, Mikhail E.,Burov, Oleg N.,Gon?alves, Anne-Marie,Goumont, Régis
, p. 6451 - 6466 (2016/02/18)
New quinoxaline 1,4-dioxide derivatives have been synthesized from novel fluorinated benzofuroxans such as 4-fluorobenzofuroxan, which is prepared for the first time. Furthermore, the preparation 4,6-difluorobenzofuroxan has been revisited because we were
2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor
Pelletier, Jeffrey C.,Chengalvala, Murty,Cottom, Josh,Feingold, Irene,Garrick, Lloyd,Green, Daniel,Hauze, Diane,Huselton, Christine,Jetter, James,Kao, Wenling,Kopf, Gregory S.,Lundquist IV, Joseph T.,Mann, Charles,Mehlmann, John,Rogers, John,Shanno, Linda,Wrobel, Jay
, p. 6617 - 6640 (2008/12/22)
Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and
