87428-53-3

Basic information

• Product Name: Ethanone, 2-hydroxy-1-(3,4,5-trimethoxyphenyl)-
• Synonyms: 2-hydroxy-1-(3,4,5-trimethoxy-phenyl)-ethanone;Ethanone,2-hydroxy-1-(3,4,5-trimethoxyphenyl);2-Hydroxy-1-(3,4,5-trimethoxy-phenyl)-aethanon
• CAS NO: 87428-53-3
• Molecular Formula: C11H14O5
• Molecular Weight: 226.229
• Mol File: 87428-53-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87-88 °C
• Boiling Point: 356.1±37.0 °C(Predicted)
• Density: 1.187±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-hydroxy-1-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-hydroxy-1-(3,4,5-trimethoxyphenyl)-(87428-53-3)
• EPA Substance Registry System: Ethanone, 2-hydroxy-1-(3,4,5-trimethoxyphenyl)-(87428-53-3)

Safety Data

• Hazardous Substances Data: 87428-53-3(Hazardous Substances Data)

Upstream product

• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 50-00-0 formaldehyd 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 51490-01-8 1-(3,4,5-trimethoxyphenyl)-2-bromoethanone 

Downstream Products

• 399040-15-4 2-amino-4-(3,4,5-trimethoxyphenyl)furan-3-carbonitrile 
• 1193107-57-1 (3,4,5-trimethoxyphenyl)(3-methylbenzofuran-2-yl)-methanone 
• 1382223-55-3 N-(4-cyanophenyl)-2-oxo-2-(3,4,5-trimethoxyphenyl)acetamide 
• 37785-48-1 2-(3,4,5-trimethoxyphenyl)ethanol 

Relevant articles and documents

Copper-Mediated SN2′ Allyl-Alkyl and Allyl-Boryl Couplings of Vinyl Cyclic Carbonates

A method for the copper-catalyzed borylmethylation and borylation of vinyl cyclic carbonates through an SN2′ mechanism is reported. These singular reactions involve selective SN2′ allylic substitutions with concomitant ring opening of the cyclic carbonate and with extrusion of CO2 and formation of a useful hydroxyl functionality in a single step. The stereoselectivity of the homoallylic borylation and allylic borylation processes can be controlled, and synthetically useful unsaturated (E)-pent-2-ene-1,5-diols and (E)-but-2-ene-1,4-diols are accessed.

Synthesis of new 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines via the Taylor ring transformation/ring annulation strategy

Selected examples 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines with a phenyl or benzyl group at the 5-position were synthesized as inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii and Toxoplasma gondii, two potentially life-threatening opportunistic pathogens associated with AIDS and other disorders of the immune system. Aldol condensation of paraformaldehyde with substituted benzaldehydes or with phenylacetaldehyde afforded α-hydroxyketones with a phenyl or benzyl group at the 4-position. Further reaction of the hydroxyketones with malononitrile afforded 2-aminofuran-3-carbonitriles, which upon heating with guanidine underwent ring transformation/ring annulation to produce 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines rather than 2,4-diaminofuro[2,3-d]pyrimidines. One of the target compounds obtained in this manner, 2,4-diamino-5-(3,4,5-trimethoxyphenyl)-7H-pyrrolo [2,3 -d]pyrimidine (1d), may be viewed as a conformationally restricted analogue of trimethoprim, an antimicrobial agent widely used in combination with a sulfa drug to treat P. carinii and T. gondii opportunistic infections in patients with AIDS. Compound 1d inhibited P. carinii and T. gondii DHFR with IC50 values of 8.3 and 14 μM, respectively. This potency was somewhat greater than that of trimethoprim. However, because this compound was also more potent than trimethoprim against mammalian (rat liver) DHFR rat liver it lacked species selectivity. The other 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidines synthesized were neither potent nor selective.