874290-90-1 Usage
Description
4-CYANOPYRIDIN-3-YLBORONIC ACID, also known as B-(4-Cyano-3-pyridinyl)boronic Acid, is an organic compound characterized by the presence of a boronic acid group attached to a pyridine ring with a cyano substituent. This unique structure endows it with versatile chemical properties, making it a valuable building block in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
4-CYANOPYRIDIN-3-YLBORONIC ACID is used as a key reactant for the synthesis of cannabinoid-1 receptor (CB1R) agonists. These agonists are important in the development of drugs targeting the endocannabinoid system, which plays a crucial role in various physiological processes, including pain, appetite, mood, and memory. The agonists can be employed for the treatment of a range of conditions, such as chronic pain, obesity, and neurological disorders.
Additionally, due to its reactivity and structural features, 4-CYANOPYRIDIN-3-YLBORONIC ACID can be utilized in the synthesis of other bioactive compounds and pharmaceutical agents, contributing to the advancement of drug discovery and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 874290-90-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,2,9 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 874290-90:
(8*8)+(7*7)+(6*4)+(5*2)+(4*9)+(3*0)+(2*9)+(1*0)=201
201 % 10 = 1
So 874290-90-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BN2O2/c8-3-5-1-2-9-4-6(5)7(10)11/h1-2,4,10-11H
874290-90-1Relevant articles and documents
Synthesis of ortho-cyanopyridylboronic acids and esters toward cyano-functionalized bipyridines
Cailly, Thomas,Fabis, Frédéric,Bouillon, Alexandre,Lema?tre, Stéphane,Sopkova, Jana,De Santos, Olivieira,Rault, Sylvain
, p. 53 - 56 (2007/10/03)
This work describes the synthesis of ortho-cyanopyridylboronic acids and esters. Their reactivity with pyridine halides in the Suzuki cross-coupling reaction is evaluated and shows that the cyanopyridyl boronic esters appear to be more stable than their corresponding acids. These esters allowed us to synthesize new cyanobipyridine systems. Georg Thieme Verlag Stuttgart.
