874383-01-4

Basic information

• Product Name: (1'R,4'R)-1-[2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone
• Synonyms: (1'R,4'R)-1-[2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone
• CAS NO: 874383-01-4
• Molecular Weight: 315.369
• Mol File: 874383-01-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'R,4'R)-1-[2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,4'R)-1-[2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone(874383-01-4)
• EPA Substance Registry System: (1'R,4'R)-1-[2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone(874383-01-4)

Safety Data

• Hazardous Substances Data: 874383-01-4(Hazardous Substances Data)

Upstream product

• 874382-95-3 (1'R,4'R)-1-[5'-tert-butyldiphenylsilyl-2',3'-dideoxy-α-L-ribofuranosyl]-2-methyl-3-benzyloxy-4-pyridinone 
• 118-71-8 Maltol 
• 61160-18-7 3-benzyloxy-2-methyl-1H-pyridin-4-one 
• 61049-69-2 3-O-benzylmaltol 
• 52813-63-5 (5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone 
• 100-39-0 benzyl bromide 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 
• 203301-81-9 (4R)-1-O-acetyl-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-L-ribofuranose 
• 201472-30-2 (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol 

Relevant articles and documents

Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives

A series of cyclic and acyclic nucleoside analogues derived from 3-hydroxy-4-pyridinone were synthesized using the Vorbrüggen reaction. Iron chelation studies, and antiviral evaluation against a broad panel of viruses, were performed. The pKa value of ligand 25 and the stability constant of the corresponding iron-(III) complex were compared to those of deferiprone. The pFe3+ values were found to be similar. Some compounds showed moderate activity against both wild-type HSV-1 and HSV-2, as well as against a thymidine kinase deficient strain of HSV-1. These results suggest a novel mode of action for this group of nucleoside analogues.