87462-63-3 Usage
Description
6-Heptyn-1-ol, 4-methylbenzenesulfonate, also known as Hept-6-yn-1-yl 4-methylbenzenesulfonate, is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media, while the tosyl group serves as an excellent leaving group for nucleophilic substitution reactions. The propargyl group allows for reactions with azide-bearing compounds or biomolecules through copper-catalyzed azide-alkyne Click Chemistry, resulting in a stable triazole linkage.
Uses
Used in Bioconjugation:
6-Heptyn-1-ol, 4-methylbenzenesulfonate is used as a bioconjugation agent for the attachment of biomolecules to various surfaces or other molecules. The propargyl group enables the formation of stable triazole linkages through copper-catalyzed azide-alkyne Click Chemistry, allowing for the efficient and specific attachment of biomolecules.
Used in Drug Delivery Systems:
6-Heptyn-1-ol, 4-methylbenzenesulfonate is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The hydrophilic PEG spacer enhances solubility in aqueous media, while the tosyl group can be utilized for nucleophilic substitution reactions to attach drug molecules or other functional groups.
Used in Chemical Synthesis:
6-Heptyn-1-ol, 4-methylbenzenesulfonate is used as an intermediate in the synthesis of various organic compounds. The tosyl group serves as a versatile leaving group, facilitating nucleophilic substitution reactions, while the propargyl group can participate in copper-catalyzed azide-alkyne Click Chemistry for the formation of triazole-containing compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 87462-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,4,6 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 87462-63:
(7*8)+(6*7)+(5*4)+(4*6)+(3*2)+(2*6)+(1*3)=163
163 % 10 = 3
So 87462-63-3 is a valid CAS Registry Number.
87462-63-3Relevant articles and documents
POTENT AND SELECTIVE DEGRADERS OF ALK
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Paragraph 00277-00278, (2021/09/04)
Disclosed are bispecific compounds (degraders) that target ALK or ALK and FAK for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the bispecific compounds to treat diseases and disorders characterized or mediated by aberrant ALK or ALK and FAK activity.
Threading of three rings on two stations: a convergent approach to [4]rotaxane
Jia, Along,Li, Xiaowei,Liu, Menglong,Liu, Yuchen,Liu, Zejiang,Wu, Jinyang,Xiao, Xin,Xu, Weitao,Yuan, Lihua,Zhou, Yidan
supporting information, p. 13506 - 13509 (2021/12/23)
A novel approach to efficient and selective construction of [4]rotaxane was proposed to demonstrate the superiority of H-bonded azo-macrocycles in forging higher order rotaxanes. The single crystal structure reveals the importance of the interplay of mult
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders
Su, Shang,Yang, Zimo,Gao, Hongying,Yang, Haiyan,Zhu, Songbiao,An, Zixuan,Wang, Juanjuan,Li, Qing,Chandarlapaty, Sarat,Deng, Haiteng,Wu, Wei,Rao, Yu
supporting information, p. 7575 - 7582 (2019/08/20)
A focused PROTAC library hijacking cancer therapeutic target CDK6 was developed. A design principle as "match/mismatch" was proposed for understanding the degradation profile differences in these PROTACs. Notably, potent PROTACs with specific and remarkable CDK6 degradation potential were generated by linking CDK6 inhibitor palbociclib and E3 ligase CRBN recruiter pomalidomide. The PROTAC strongly inhibited proliferation of hematopoietic cancer cells including multiple myeloma and robustly degraded copy-amplified/mutated forms of CDK6, indicating future potential clinical applications.
