874752-04-2

Basic information

• Product Name: Benzoic acid, 2-(5-nitro-1H-indol-2-yl)-4-(phenylmethoxy)-
• CAS NO: 874752-04-2
• Molecular Formula: C22H16N2O5
• Molecular Weight: 388.379
• Mol File: 874752-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(5-nitro-1H-indol-2-yl)-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(5-nitro-1H-indol-2-yl)-4-(phenylmethoxy)-(874752-04-2)
• EPA Substance Registry System: Benzoic acid, 2-(5-nitro-1H-indol-2-yl)-4-(phenylmethoxy)-(874752-04-2)

Safety Data

• Hazardous Substances Data: 874752-04-2(Hazardous Substances Data)

Upstream product

• 1486-51-7 p-(benzyloxy)benzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 100-39-0 benzyl bromide 
• 56442-22-9 benzyl 4-benzyloxybenzoate 
• 874752-01-9 9-benzyloxy-2-nitroisoindolo[2,1-a]indol-6-one 
• 874751-98-1 1-(4-benzyloxybenzoyl)-5-nitro-1H-indole 
• 874751-95-8 9-hydroxy-2-nitroisoindolo[2,1-a]indol-6-one 

Relevant articles and documents

Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors

In order to develop structure-activity relationships and to provide access to antibacterial agents for dual action studies, a variety of aryl group-substituted 2-aryl-5-nitro-1H-indoles were synthesized and the activity of the compounds assessed as inhibitors of the NorA multidrug resistance pump in the bacterium Staphylococcus aureus. The NorA protein from the major facilitator superfamily of efflux pumps confers resistance to a variety of structurally dissimilar antimicrobials such as norfloxacin, ethidium bromide, berberine and acriflavin. The compound [4-benzyloxy-2-(5-nitro-1H-2-yl)-phenyl]-methanol was the most potent pump inhibitor.