874784-09-5

Basic information

• Product Name: 5-(5-BroMo-2-fluorophenyl)-2H-tetrazole
• Synonyms: 5-(5-BroMo-2-fluorophenyl)-2H-tetrazole
• CAS NO: 874784-09-5
• Molecular Formula: C₇H₄BrFN₄
• Molecular Weight: 243.0358632
• Mol File: 874784-09-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(5-BroMo-2-fluorophenyl)-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(5-BroMo-2-fluorophenyl)-2H-tetrazole(874784-09-5)
• EPA Substance Registry System: 5-(5-BroMo-2-fluorophenyl)-2H-tetrazole(874784-09-5)

Safety Data

• Hazardous Substances Data: 874784-09-5(Hazardous Substances Data)

Usage

General Description

5-(5-Bromo-2-fluorophenyl)-2H-tetrazole is a chemical compound with the molecular formula C7H4BrFN4. It is a tetrazole derivative that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 5-(5-Bromo-2-fluorophenyl)-2H-tetrazole is a white to off-white crystalline powder that is soluble in organic solvents but insoluble in water. It has been studied for its potential use as a bioactive agent and as a component in the development of new materials. Additionally, 5-(5-Bromo-2-fluorophenyl)-2H-tetrazole may also exhibit potential antimicrobial and antifungal properties, making it a versatile compound with various potential applications in the fields of medicine and materials science.

Upstream product

• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 

Downstream Products

• 1262519-14-1 C₁₂H₇FN₄O₂ 

Relevant articles and documents

Design, synthesis, and biological activity of novel 5-((arylfuran/1 H -pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl) thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41

On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3- (trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds 12a-o effectively inhibited infection by both laboratory-adapted and primary HIV-1 strains and blocked HIV-1 mediated cell-cell fusion and gp41 six-helix bundle formation. Molecular docking analyses on two highly active inhibitors, 12b, containing a carboxylic acid group, and 12m, containing a tetrazole group, indicated that they both fit snugly into the hydrophobic cavity of HIV-1 gp41 from which each has important ionic interactions with lysine 574 (K574). By contrast, molecular docking of 12i, a less active compound containing a pyrrole instead of a furan ring, indicated a completely different orientation from 12b and 12m and missed critical interactions.