874916-38-8Relevant articles and documents
Facile construction of the pentacyclic framework of subincanadine B. Synthesis of 20-deethylenylated subincanadine B and 19,20-dihydrosubincanadine B
Liu, Yanqin,Luo, Shengjun,Fu, Xingnian,Fang, Fang,Zhuang, Zeyang,Xiong, Wanting,Jia, Xueshun,Zhai, Hongbin
, p. 115 - 118 (2006)
(Chemical Equation Presented) We describe a facile approach for effectively constructing the pentacyclic framework of subincanadine B. The seven-step assembly of tetracyclic ketone 14 featured Michael addition, Pictet-Spengler cyclization, and Dieckmann condensation. From this key ketone intermediate, two analogues of subincanadine B, i.e., 20-deethylenylated subincanadine B (27) and 19,20-dihydrosubincanadine B (31), were synthesized in four steps, respectively.