874988-27-9Relevant articles and documents
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies
Mahindroo, Neeraj,Wang, Chiung-Chiu,Liao, Chun-Chen,Huang, Chien-Fu,Lu, I.-Lin,Lien, Tzu-Wen,Peng, Yi-Huei,Huang, Wei-Jan,Lin, Ying-Ting,Hsu, Ming-Chen,Lin, Chia-Hui,Tsai, Chia-Hua,Hsu, John T.-A.,Chen, Xin,Lyu, Ping-Chiang,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang
, p. 1212 - 1216 (2007/10/03)
A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligan
