875-28-5 Usage
Physical state
Crystalline solid This compound exists in a solid state with a crystal-like structure, which gives it a distinct appearance and texture.
Solubility
Soluble in water 2,3-dihydroxybenzoic acid can dissolve in water, which makes it suitable for various applications, including pharmaceuticals and chemical reactions.
Uses
Precursor for organic synthesis 2,3-dihydroxybenzoic acid is commonly used as a starting material in the synthesis of various organic compounds, making it an important building block in chemical manufacturing.
6. Applications in pharmaceuticals and dyes Due to its versatile chemical properties, this compound is often utilized in the production of pharmaceuticals and dyes, contributing to a wide range of products and industries.
7. Antioxidant properties 2,3-dihydroxybenzoic acid has been found to possess antioxidant properties, which can help protect cells from damage caused by free radicals and oxidative stress.
9. Research on neurodegenerative diseases and cancer treatment 2,3-dihydroxybenzoic acid has been studied for its potential applications in the treatment of neurodegenerative diseases and cancer due to its ability to inhibit certain enzymes and pathways involved in disease progression, making it an interesting subject for further research and development in the field of medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 875-28-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,7 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 875-28:
(5*8)+(4*7)+(3*5)+(2*2)+(1*8)=95
95 % 10 = 5
So 875-28-5 is a valid CAS Registry Number.
875-28-5Relevant articles and documents
Thiol-disulfide exchanges modulate aldo-keto reductase family 1 member B10 activity and sensitivity to inhibitors
Shen, Yi,Zhong, Linlin,Markwell, Stephen,Cao
experimental part, p. 530 - 537 (2011/11/30)
The reversible thiol/disulfide exchange is an important regulatory mechanism of protein enzymatic activity. Many protein enzymes are susceptible to S-thiolation induced by reactive oxygen species (ROS); and the glutathione (GSH) and free amino acid cysteine (Cys) are critical cellular thiol anti-oxidants, protecting proteins from irreversible oxidative damage. In this study, we found that aldo-keto reductase family 1 member B10 (AKR1B10) contains 4 Cys residues, i.e., Cys45, Cys187, Cys200, and Cys299. Exposing AKR1B10 to ROS mixtures resulted in significant decrease of its free sulfhydryl groups, up to 40-50% in the presence of physiological thiol cysteine at 0.5 or 1.0 mM; and accordingly, AKR1B10 enzymatic activity was reversibly decreased, in parallel with the oxidation of the sulfhydryl groups. ROS-induced thiolation also affected the sensitivity of AKR1B10 to inhibitors EBPC, epalrestat, and statil. Together our results showed for the first time that AKR1B10's enzymatic activity and inhibitor sensitivity are modulated by thiol/disulfide exchanges.
