875126-51-5 Usage
Description
4-(1-Piperidinylmethyl)-benzenemethanaminedihydrochloride, also known as Nefopam, is a non-opioid analgesic that functions by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. It is recognized for its efficacy in managing moderate to severe pain without the risk of addiction and respiratory depression associated with opioids.
Used in Pharmaceutical Industry:
4-(1-Piperidinylmethyl)-benzenemethanaminedihydrochloride is used as a pain management agent for treating conditions such as postoperative pain, cancer pain, and musculoskeletal pain. It is favored for its lower potential for addiction compared to opioid painkillers, making it a safer alternative in certain patient populations.
Used in Pain Management:
4-(1-Piperidinylmethyl)-benzenemethanaminedihydrochloride serves as an analgesic to alleviate moderate to severe pain, offering an effective treatment option with a reduced risk of respiratory depression and addiction, which are common concerns with opioid类药物.
Used in Patient Care:
4-(1-Piperidinylmethyl)-benzenemethanaminedihydrochloride is used as a therapeutic intervention for patients with a history of substance abuse or psychiatric disorders, where the use of opioids may pose a higher risk of adverse effects and complications.
Check Digit Verification of cas no
The CAS Registry Mumber 875126-51-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,5,1,2 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 875126-51:
(8*8)+(7*7)+(6*5)+(5*1)+(4*2)+(3*6)+(2*5)+(1*1)=185
185 % 10 = 5
So 875126-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H20N2.2ClH/c14-10-12-4-6-13(7-5-12)11-15-8-2-1-3-9-15;;/h4-7H,1-3,8-11,14H2;2*1H
875126-51-5Relevant articles and documents
Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity
D'Amico, Derin C.,Aya, Toshi,Human, Jason,Fotsch, Christopher,Chen, Jian Jeffrey,Biswas, Kaustav,Riahi, Bobby,Norman, Mark H.,Willoughby, Christopher A.,Hungate, Randall,Reider, Paul J.,Biddlecome, Gloria,Lester-Zeiner, Dianna,Van Staden, Carlo,Johnson, Eileen,Kamassah, Augustus,Arik, Leyla,Wang, Judy,Viswanadhan, Vellarkad N.,Groneberg, Robert D.,Zhan, James,Suzuki, Hideo,Toro, Andras,Mareska, David A.,Clarke, David E.,Harvey, Darren M.,Burgess, Laurence E.,Laird, Ellen R.,Askew, Benny,Ng, Gordon
, p. 607 - 610 (2007/10/03)
We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4-17 nM). At 90 mg/kg s.c., 28 decreased plasma extravasation in two rodent models of inflammation. A novel met
