87551-45-9

Basic information

• Product Name: 1H-pyrazole-4-carbohydrazide(SALTDATA: FREE)
• Synonyms: 1H-pyrazole-4-carbohydrazide(SALTDATA: FREE)
• CAS NO: 87551-45-9
• Molecular Formula: C4H6N4O
• Molecular Weight: 126.11664
• Mol File: 87551-45-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-pyrazole-4-carbohydrazide(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrazole-4-carbohydrazide(SALTDATA: FREE)(87551-45-9)
• EPA Substance Registry System: 1H-pyrazole-4-carbohydrazide(SALTDATA: FREE)(87551-45-9)

Safety Data

• Hazardous Substances Data: 87551-45-9(Hazardous Substances Data)

Usage

Chemical structure

A pyrazole ring with a carbohydrazide group attached to it

Type of compound

A hydrazide derivative of pyrazole

Common uses

In the synthesis of various organic compounds

Known for

Versatile reactivity

Potential applications

Pharmaceuticals, agrochemicals, and materials science

Safety precautions

Handle with care to avoid potential health hazards

Importance

Valuable chemical compound with a wide range of potential applications in various fields.

Upstream product

• 80981-25-5 1,3-Dimethyl-1-(1H-pyrazole-4-carbonyl)-urea 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 37718-11-9 1H-pyrazole-4-carboxylic acid 
• 51105-90-9 methyl pyrazole-4-carboxylate 
• 37622-90-5 4-ethoxycarbonylpyrazole 
• 129819-40-5 ethyl 1-(difluoromethyl)pyrazole-4-carboxylate 

Relevant articles and documents

[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES

The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Structure-activity relationship studies and biological characterization of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors

The structure-activity relationship (SAR) study of two chemotypes identified as inhibitors of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD, 15-PGDH) was conducted. Top compounds from both series displayed potent inhibition (IC50 2 production in A549 lung cancer and LNCaP prostate cancer cells.