875514-20-8

Basic information

• Product Name: 8-BROMO-[1,6]NAPHTHYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE
• Synonyms: 8-BROMO-[1,6]NAPHTHYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE;methyl 8-bromo-1,6-naphthyridine-2-carboxylate
• CAS NO: 875514-20-8
• Molecular Formula: C10H8BrN3O
• Molecular Weight: 266.09
• Mol File: 875514-20-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 388.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.627±0.06 g/cm3(Predicted)
• PKA: 0.17±0.30(Predicted)
• CAS DataBase Reference: 8-BROMO-[1,6]NAPHTHYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-[1,6]NAPHTHYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE(875514-20-8)
• EPA Substance Registry System: 8-BROMO-[1,6]NAPHTHYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE(875514-20-8)

Safety Data

• Hazardous Substances Data: 875514-20-8(Hazardous Substances Data)

Upstream product

• 197507-55-4 8-bromo-[1,6]-naphthyridine-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 197507-59-8 1,6-naphthyridine-2-carboxylic acid 

Downstream Products

• 1611473-55-2 8-(4-methoxyphenyl)-1,6-naphthyridine-2-carboxylic acid 
• 887454-04-8 8-(4-methoxyphenyl)-N-phenethyl-1,6-naphthyridine-2-carboxamide 
• 1611472-01-5 8-(4-methoxyphenyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-02-6 8-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-03-7 8-(4-methoxyphenyl)-N-(pyridin-2-ylmethyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-05-9 8-(4-methoxyphenyl)-N-(3-phenylpropyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-13-9 N-benzyl-8-(4-methoxyphenyl)-N-methyl-1,6-naphthyridine-2-carboxamide 
• 1611472-14-0 N-benzyl-N-(2-methoxyethyl)-8-(4-methoxyphenyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-15-1 8-(4-methoxyphenyl)-N-(3,3,3-trifluoropropyl)-1,6-naphthyridine-2-carboxamide 
• 1611472-22-0 N-(3-(3,5-dimethyl-1H-pyrazol-1-yl)propyl)-8-(4-methoxyphenyl)-1,6-naphthyridine-2-carboxamide 

Relevant articles and documents

NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS

The present invention relates to naphthyridine and isoquinoline compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of CDK8/19, and for the treatment of CDK8/19-related disorders.

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.