875629-46-2

Basic information

• Product Name: [3-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester
• Synonyms: [3-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester
• CAS NO: 875629-46-2
• Molecular Weight: 367.215
• Mol File: 875629-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester(875629-46-2)
• EPA Substance Registry System: [3-(4-bromo-2-fluoro-benzyloxy)-phenyl]-acetic acid ethyl ester(875629-46-2)

Safety Data

• Hazardous Substances Data: 875629-46-2(Hazardous Substances Data)

Upstream product

• 51436-99-8 2-fluoro-4-bromotoluene 
• 22446-38-4 ethyl 3-hydroxyphenylacetate 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 

Relevant articles and documents

Synthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors

In the course of our ongoing studies several substituted benzyloxyphenylacetic acids were prepared. Comparison of their aldose reductase inhibition with the biological activity obtained for recently evaluated benzoic acid analogues revealed the critical role of a methylene spacer between the aromatic core and the acidic function. Starting from the most potent derivative (i.e. 5d, IC50 = 20.9 μM) further structural modifications were performed and their influence on the inhibitory effect was established.