875664-54-3

Basic information

• Product Name: 3,4-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• Synonyms: 3,4-DIFLUOROPHENYLHYDRAZINE HCL;N'-(3,4-DIFLUORO-PHENYL)-HYDRAZINIUM, CHLORIDE;3,4-Difluorophenylhydrazine hydrochloride;1,2-Difluoro-4-hydrazinobenzene hydrochloride;3,4-Difluorophenylhydrazine hydrogen chloride
• CAS NO: 875664-54-3
• Molecular Formula: C6H7ClF2N2
• Molecular Weight: 180.58
• Mol File: 875664-54-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 230°C
• Boiling Point: Safety Data
  1. Xi
  2. N/A
  3. N/A
  6. IRRITANT
  7. N/A
  8. 875664-54-3(Hazardous Substances Data)
• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 875664-54-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H3ClF6O2/c10-6-4(8(11,12)13)1-3(7(17)18)2-5(6)9(14,15)16/h1-2H,(H,17,18)

Upstream product

• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 221031-08-9 4,5-dibromo-2-(3,4-difluorophenyl)-2H-pyridazin-3-one 
• 1588396-86-4 methyl 1-(3,4-difluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide 
• 1432509-30-2 methyl 4-((6,7-difluoro-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)benzoate 
• 1432508-19-4 4-((6,7-difluoro-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)-N-hydroxybenzamide 
• 1432509-33-5 methyl 4-((5,6-difluoro-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)benzoate 
• 1432508-21-8 4-((5,6-difluoro-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)-N-hydroxybenzamide 

Relevant articles and documents

Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding

Phenylazocarboxamides can serve as bioisosteres for cinnamides, which are widely occurring substructures in medicinal chemistry. Starting from our lead compound 2, the introduction of additional fluoro substituents and the exchange of the methoxyphenylpip

Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents

Two series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 2,4-imidazolinedione/pyrazolone scaffold were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against HT-29, H460, A549, MKN-45, and U87MG cancer cell lines in vitro. The pharmacological data indicated that most of the tested compounds showed moderate to significant cytotoxicity and high selectivity against HT-29, H460 and A549 cancer cell lines as compared with foretinib. The SAR analyses indicated that compounds with halogen groups, especially trifluoromethyl groups at 2-position on the phenyl ring (moiety B) were more effective. In this study, a promising compound 17 (c-Met IC50= 2.20 nM, a multi-target tyrosine kinase inhibitor) showed the most potent antitumor activities with IC50values of 0.14 μM, 0.18 μM, 0.09 μM, 0.03 μM, and 1.06 μM against HT-29, H460, A549, MKN-45, and U87MG cell lines, respectively.