875681-02-0

Basic information

• Product Name: Carbamic acid, [(1S)-3-[[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl][(2-nitrophenyl) sulfonyl]amino]-1-methylpropyl]-, 1,1-dimethylethyl ester
• CAS NO: 875681-02-0
• Molecular Formula: C27H34N4O8S
• Molecular Weight: 574.655
• Mol File: 875681-02-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-3-[[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl][(2-nitrophenyl) sulfonyl]amino]-1-methylpropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-3-[[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl][(2-nitrophenyl) sulfonyl]amino]-1-methylpropyl]-, 1,1-dimethylethyl ester(875681-02-0)
• EPA Substance Registry System: Carbamic acid, [(1S)-3-[[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl][(2-nitrophenyl) sulfonyl]amino]-1-methylpropyl]-, 1,1-dimethylethyl ester(875681-02-0)

Safety Data

• Hazardous Substances Data: 875681-02-0(Hazardous Substances Data)

Upstream product

• 176982-57-3 (3-amino-1(S)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester 
• 875680-99-2 (S)-N¹-(o-nitrophenylsulfonyl)-N³-(tert-butyloxycarbonyl)-1,3-diaminobutane 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 5457-30-7 4-phthalimido-1-iodobutane 

Downstream Products

• 875681-04-2 (S)-N¹-phthaloyl-N⁵-(o-nitrophenylsulfonyl)-N⁸-acetyl-1,8-diamino-5-azanonane 

Relevant articles and documents

α-methyl polyamines: Efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase

Efficient syntheses of metabolically stable α-methylspermidine 1, α-methylspermine 2, and bis-α,α-methylated spermine 3 starting from ethyl 3-aminobutyrate are described. The biological tolerance for these compounds was tested in wild-type mice and transgenic mice carrying the metallothionein promoter-driven spermidine/spermine N1- acetyltransferase gene (MT-SSAT). The efficient substitution of natural polyamines by their derivatives was confirmed in vivo with the rats harboring the same MT-SSAT transgene and in vitro with the immortalized fibroblasts derived from these animals. Enantiomers of previously unknown 1-amino-8-acetamido-5-azanonane dihydrochloride 4 were synthesized starting from enantiomerically pure (R)- and (S)-alaninols. The studies with recombinant human polyamine oxidase (PAO) showed that PAO (usually splits achiral substrates) strongly favors the (R)-isomer of 4 that demonstrates for the first time that the enzyme has hidden potency for stereospecificity.