87601-32-9

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-[3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (S)-
• CAS NO: 87601-32-9
• Molecular Formula: C20H27NO5S2
• Molecular Weight: 425.57
• Mol File: 87601-32-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-[3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-[3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (S)-(87601-32-9)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-[3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, (S)-(87601-32-9)

Safety Data

• Hazardous Substances Data: 87601-32-9(Hazardous Substances Data)

Upstream product

• 7533-40-6 2-amino-4-methyl-1-pentanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2666-93-5 (S)-Leu-OMe 
• 61-90-5 L-leucine 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 

Downstream Products

• 936012-04-3 (S)-N-(1-cyano-4-methylpentan-2-yl)-4-methylbenzenesulfonamide 
• 101833-46-9 (S)-N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 20445-29-8 N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 1258948-42-3 (3RS,5S)-3-ethoxycarbonyl-5-(2-methylpropyl)-1-toluene-p-sulphonylpyrrolidin-2-one 
• 87601-33-0 Methyl-[(R)-4-methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphinic acid ethyl ester 
• 88129-47-9 [(R)-4-Methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann-L?ffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity. (Chemical Equation Presented).

SYNTHESIS OF THE RACEMIC FORM OF (Z)-1,17-DIAMINOOCTADEC-9-ENE, AN ALIPHATIC DIAMINE FROM COCCINELLIDAE. DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE (+)-NATURALLY-OCCURRING ANTIPODE

The total synthesis of the title compound (1) has been achieved.Also reported is the use of lanthanide induced shifts in 1H NMR spectroscopy to assign the absolute configuration of the α-carbon atom in chiral primary α-methylalkylamines.Application of this empirical method to natural (+)-1 shows that it has the R-configuration at C-17.