876149-55-2

Basic information

• Product Name: 2-Propen-1-one, 1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)-
• CAS NO: 876149-55-2
• Molecular Formula: C11H12BrNO2
• Molecular Weight: 270.126
• Mol File: 876149-55-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)-(876149-55-2)
• EPA Substance Registry System: 2-Propen-1-one, 1-(4-bromo-2-hydroxyphenyl)-3-(dimethylamino)-(876149-55-2)

Safety Data

• Hazardous Substances Data: 876149-55-2(Hazardous Substances Data)

Upstream product

• 288067-35-6 4-bromo-2-hydroxy-benzonitrile 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 18442-22-3 7-Bromo-2,3-dihydro-4H-chromen-4-one 
• 1159978-70-7 3,7-dibromo-4H-chromen-4-one 

Relevant articles and documents

TBN-triggered, manipulable annulations of: O -hydroxyarylenaminones for divergent syntheses of oximinochromanones and oximinocoumaranones

Divergent synthesis provides an indispensable route to rapid acquisition of structurally diverse chemical scaffolds from identical starting materials. Herein, we describe unprecedented divergent annulations of o-hydroxyarylenaminones promoted by tert-butyl nitrite (TBN) under mild conditions. Two different types of benzo-oxa-heterocycle, including oximinochromanones and oximinocoumaranones, were smoothly assembled with a broad substrate scope and good functional group compatibility.

Iron-Catalyzed Regioselective Decarboxylative Alkylation of Coumarins and Chromones with Alkyl Diacyl Peroxides

A facile iron-catalyzed decarboxylative radical coupling of alkyl diacyl peroxides with coumarins or chromones has been developed, affording a highly efficient approach to synthesize a variety of α-alkylated coumarins and β-alkylated chromones. The reaction proceeded smoothly without adding any ligand or additive and provided the corresponding products containing a wide scope of functional groups in moderate to excellent yields. This protocol was highlighted by its high regioselectivity, readily available starting materials, and operational simplicity.

CHROMANE-SUBSTITUED TETRACYCLIC COMPOUNDS AND USES THEREOF FOR TREATMENT OF VIRAL DISEASES

Disclosed are novel chromane-substituted tetracyclic compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, A', R2 R3, R4 and R5 are as defined in the description. Also disclosed are compositions comprising a chromane-substituted tetracyclic compound, and methods of using the chromane-substituted tetracyclic compounds for treating or preventing HCV infection in a patient.