876372-87-1

Basic information

• Product Name: 6-BROMO-3-TERT-BUTYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE
• Synonyms: 6-BROMO-3-TERT-BUTYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE
• CAS NO: 876372-87-1
• Molecular Formula: C₁₀H₁₂BrN₃
• Molecular Weight: 254.13
• Mol File: 876372-87-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-BROMO-3-TERT-BUTYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-3-TERT-BUTYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE(876372-87-1)
• EPA Substance Registry System: 6-BROMO-3-TERT-BUTYL-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE(876372-87-1)

Safety Data

• Hazardous Substances Data: 876372-87-1(Hazardous Substances Data)

Upstream product

• 58910-26-2 ethyl 2,2-dimethylpropanimidoate hydrochloride 
• 77992-44-0 5-bromo-2-hydrazinylpyridine 

Downstream Products

• 876372-76-8 3-tert-butyl-6-[(2,6-dichlorophenyl)thio][l,2,4]triazolo[4,3-a]pyridine 
• 876372-60-0 3-tert-butyl-6-[(2,4-difluorophenyl)thio][1,2,4]triazolo[4,3-a]pyridine 

Relevant articles and documents

A mild synthesis of [1,2,4]triazolo[4,3-a]pyridines

The reaction between 2-hydrazinopyridines and ethyl imidates was examined as a one-pot method for rapidly preparing [1,2,4]triazolo[4,3-a]pyridines. A diverse set of 2-hydrazinopyridines were cyclized with a variety of alkyl- and aryl-substituted ethyl imidates in good yields. The reaction proceeds optimally under mild conditions (50-70 C) using 1.5 equiv of acetic acid. The electronic and steric properties of the hydrazine and imidate strongly impact the rate of the reaction. When highly electron deficient 2-hydrazinopyridines were used, the products rearranged to [1,2,4]triazolo[1,5-a]pyridines.