876514-43-1

Basic information

• Product Name: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide
• Synonyms: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide
• CAS NO: 876514-43-1
• Molecular Weight: 374.283
• Mol File: 876514-43-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide(876514-43-1)
• EPA Substance Registry System: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]-di(2-methylpropionitrile) hydrobromide(876514-43-1)

Safety Data

• Hazardous Substances Data: 876514-43-1(Hazardous Substances Data)

Upstream product

• 120511-84-4 2-[3-bromomethyl-5-(cyanodimethylmethyl)phenyl]-2-methylpropanenitrile 
• 41253-21-8 sodium triazole 

Downstream Products

• 120511-73-1 anastrozol 

Relevant articles and documents

Novel processes for preparing substantially pure anastrozole

The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.