876694-43-8

Basic information

• Product Name: 3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98
• Synonyms: 3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98;3-Bromo-N-cyclopropylbenzenesulphonamide 98%;N-Cycloypropyl 3-bromophenylsulfonamide
• CAS NO: 876694-43-8
• Molecular Formula: C₉H₁₀BrNO₂S
• Molecular Weight: 276.153
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 876694-43-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 171
• Boiling Point: 385.299 °C at 760 mmHg
• Flash Point: 186.823 °C
• Appearance: /
• Density: 1.706g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98(876694-43-8)
• EPA Substance Registry System: 3-BROMO-N-CYCLOPROPYLBENZENESULPHONAMIDE 98(876694-43-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 876694-43-8(Hazardous Substances Data)

Usage

General Description

3-Bromo-N-cyclopropylbenzenesulphonamide 98 is a chemical compound used in various industrial and research applications. It is a sulphonamide derivative with a molecular formula of C8H9BrNO2S and a molecular weight of 263.13 g/mol. This chemical is commonly utilized as a building block in the synthesis of pharmaceuticals, agrochemicals, and various other organic compounds. It is also used as a reagent in chemical reactions and as a substrate for chemical research purposes. Due to its versatile properties and potential applications, 3-Bromo-N-cyclopropylbenzenesulphonamide 98 is an important chemical compound in the field of organic chemistry.

InChI:InChI=1/C9H10BrNO2S/c10-7-2-1-3-9(6-7)14(12,13)11-8-4-5-8/h1-3,6,8,11H,4-5H2

Upstream product

• 2905-24-0 3-Bromobenzenesulfonyl chloride 
• 765-30-0 Cyclopropylamine 

Downstream Products

• 1355554-11-8 N-cyclopropyl-3-(3,5-dimethyl-4-isoxazolyl)benzenesulfonamide 
• 1416367-02-6 N-cyclopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide 

Relevant articles and documents

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

A highly diastereoselective, visible-light-induced [3 + 2] cycloaddition between N-sulfonyl cyclopropylamines and electron-deficient olefins is reported. The reactions proceed via the oxidation of a sulfonamide aza-anion by an organic photocatalyst to generate a nitrogen-centered radical. Strain-induced ring opening and intermolecular addition to the olefin generate an intermediate carbon-centered radical that is reduced to an anion prior to 5-exo cyclization. This enables a highly diastereoselective construction of trans-cyclopentanes possessing synthetically useful functional groups.

STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES

The application relates to compounds of Formula (I'): which modulate the activity of a kinase (e.g., STK4), a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease or disorder associated with the modulation of a kinase, such as STK4.

SUBSTITUTED PYRIMIDINYL AND PYRIDINYL-PYRROLOPYRIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

The present invention relates to substituted pyrimidinyl- and pyridinylpyrrolopyridinone compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.