87693-75-2

Basic information

• Product Name: Piperazinone, 4-(cyclohexylcarbonyl)-6-hydroxy-1-(2-phenylethyl)-
• Synonyms: 4-(cyclohexylcarbonyl)-6-hydroxy-1-phenethylpiperazine-2-one;4-(cyclohexylcarbonyl)-2-hydroxy-6-oxo-1-phenethyl piperazine;1-(2-phenyl)ethyl-4-cyclohexanecarbonyl-2-hydroxypiperazine-6-one;4-(cyclohexylcarbonyl)-6-hydroxy-1-(2-phenylethyl)piperazin-2-one
• CAS NO: 87693-75-2
• Molecular Formula: C19H26N2O3
• Molecular Weight: 330.427
• Mol File: 87693-75-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperazinone, 4-(cyclohexylcarbonyl)-6-hydroxy-1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazinone, 4-(cyclohexylcarbonyl)-6-hydroxy-1-(2-phenylethyl)-(87693-75-2)
• EPA Substance Registry System: Piperazinone, 4-(cyclohexylcarbonyl)-6-hydroxy-1-(2-phenylethyl)-(87693-75-2)

Safety Data

• Hazardous Substances Data: 87693-75-2(Hazardous Substances Data)

Upstream product

• 17376-04-4 2-phenethyl iodide 
• 87693-74-1 4-(cyclohexanecarbonyl)-1-phenethylpiperazine-2,6-dione 
• 13156-95-1 2-chloro-N-phenethylacetamide 
• 64-04-0 phenethylamine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 87693-72-9 4-(cyclohexylcarbonyl)-2,6-di-hydroxyiminopiperazine 
• 87693-73-0 4-(cyclohexylcarbonyl)-2,6-dioxopiperazine 
• 87693-71-8 Cyclohexanecarboxylic acid bis-cyanomethyl-amide 

Downstream Products

• 94494-35-6 4-(cyclohexylcarbonyl)-3,4-dihydro-1-(2-phenylethyl)-2(1H)-pyrazinone 
• 55268-74-1 2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one 

Relevant articles and documents

A concise and highly efficient synthesis of praziquantel as an anthelmintic drug

A concise and practical synthesis of praziquantel as anthelmintic drug is described. The key steps include a monoalkylation of ethanolamine for the preparation of 2-(2-hydroxyethylamino)-N-phenethylacetamide and a mild oxidation protocol with SO3-Py/DMSO as oxidant to transform alcohol into the corresponding aza-acetal. The telescoped synthesis is composed of five steps without purification of the intermediates, providing an overall yield of 80% with 99.8% purity after crystallization.

NEW SYNTHESES OF PRAZIQUANTEL : 2-(CYCLOHEXYLCARBONYL)-1,2,3,6,7,11b-HEXAHYDRO-4H-PYRAZINOISOQUINOLIN-4-ONE

This paper describes two different synthetic pathways for praziquantel, a new broad spectrum schistosomicide and cestocide.Easy to apply on an industrial scale, they involve a selective reduction of 4-acyl-1-phenethylpiperazine-2,6-dione in 4-acyl-6-hydroxy-1-phenethylpiperazin-2-one, the cyclisation of wchich in acetic medium gives tricyclic compounds 2-acyl-1,2,3,6,7,11b-hexahydro-4H-pyrazinisoquinolin-4-one.