87700-65-0Relevant articles and documents
Process Development, Manufacture, and Understanding of the Atropisomerism and Polymorphism of Verinurad
Ring, Oliver T.,Hayter, Barry R.,Ronson, Thomas O.,Agnew, Lauren R.,Ashworth, Ian W.,Cherryman, Janette,Gall, Malcolm A. Y.,Hamilton, Peter R.,Inglesby, Phillip A.,Jones, Martin F.,Lamacraft, Alex L.,Leahy, Adam J.,McKinney, David,Miller-Potucka, Lucie,Powell, Lyn,Putra, Okky D.,Robbins, Andrew J.,Tomasi, Simone,Wordsworth, Rosemary A.
, p. 936 - 948 (2021/11/16)
The manufacturing route toward verinurad, an amphoteric, class II atropisomer that readily forms solvates, has proven to be highly complex. This previously required the isolation of intermediates with challenging physical properties and the application of cryogenic processes. New processes were designed and optimized, enabling the manufacture of 113 kg of verinurad in its desired polymorphic form. An interdisciplinary approach involving the synthesis, high-throughput experimentation, analytical chemistry, crystallization science, in silico modeling, and engineering was employed. Kinetic measurement of enantiomerically enriched verinurad salts confirmed that racemization occurred within the clearance time frame, thus mitigating safety concerns associated with inherent axial chirality in verinurad.
Palladium-catalyzed directing group-assisted C8-triflation of naphthalenes
Yang, Zhi-Wei,Zhang, Qi,Jiang, Yuan-Ye,Li, Lei,Xiao, Bin,Fu, Yao
supporting information, p. 6709 - 6711 (2016/06/01)
The transition-metal-catalyzed direct triflation of naphthyl amides and naphthyl ketones has been accomplished for the first time. Benzophenone (BP) was found to be a suitable ligand for the cross-coupling reactions. Density functional theory (DFT) calculations revealed that excessive amounts of HOTf inhibit the reductive elimination of the C-F bond to realize the unusual reductive elimination of the C-OTf bond.
NAPHTHYL- OR ISOQUINOLINYL-SUBSTITUTED ISOTHIAZOLINE COMPOUNDS
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Page/Page column 152, (2015/01/16)
The present invention relates to naphthyl-or isoquinolinyl-substituted isothiazoline compounds of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in