877037-95-1

Basic information

• Product Name: 5-(2-iodo-6-methoxy-phenoxy)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester
• CAS NO: 877037-95-1
• Molecular Weight: 457.308
• Mol File: 877037-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2-iodo-6-methoxy-phenoxy)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-iodo-6-methoxy-phenoxy)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester(877037-95-1)
• EPA Substance Registry System: 5-(2-iodo-6-methoxy-phenoxy)-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester(877037-95-1)

Safety Data

• Hazardous Substances Data: 877037-95-1(Hazardous Substances Data)

Upstream product

• 263406-15-1 5-hydroxy-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester 
• 828277-29-8 5-oxo-3,4,5,6,7,8-hexahydro-1H-isoquinoline-2-carboxylic acid ethyl ester 
• 111726-46-6 2-iodo-6-methoxyphenol 

Relevant articles and documents

Stereoselective synthesis of morphine fragments trans- and cis-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolines

A stereoselective synthesis of the ACNO partial structures of morphine has been developed. Palladium-catalyzed cyclization of carbamate 2 provided the tetracyclic (ACNO) 3-ethoxycarbonyl-9-methoxy-2,3,5,6,7,7a-hexahydro-1H- benzofuro[3,2-e]isoquinoline (14); while treatment of 5-(2-bromo-6- methoxyphenoxy)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline (8) under the same reaction condition gave 8a-(2-hydroxy-3-methoxyphenyl)-1,2,3,4,6,7,8,8a- octahydroisoquinoline (11) via an unusual Claisen rearrangement. 9-Methoxy-3-methyl-2,3,5,6,7,7a-hexahydro-1H-benzofuro[3,2-e]isoquinoline (7) was successfully transformed to trans-octahydroisoquinoline 3 and cis-octahydroisoquinoline 4 via catalytical hydrogenation over PtO2 and chemical reduction with acidic NaBH4, respectively.