877060-47-4

Basic information

• Product Name: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE
• Synonyms: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE;3-IODO-5-AZAINDOLE
• CAS NO: 877060-47-4
• Molecular Formula: C₇H₅IN₂
• Molecular Weight: 244.03
• Product Categories: Heterocycle-Pyridine series
• Mol File: 877060-47-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 178-179℃
• Boiling Point: 380.547°C at 760 mmHg
• Flash Point: 183.948°C
• Appearance: /
• Density: 2.082
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.788
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(877060-47-4)
• EPA Substance Registry System: 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE(877060-47-4)

Safety Data

• Hazardous Substances Data: 877060-47-4(Hazardous Substances Data)

Usage

General Description

3-IODO-1H-PYRROLO[3,2-C]PYRIDINE is a chemical compound with the molecular formula C8H5IN2. It is a heterocyclic organic compound that contains both pyrrole and pyridine rings with an iodine atom attached to the pyrrole ring. 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceutical drugs. It may also be used as a building block in the synthesis of complex organic molecules. 3-IODO-1H-PYRROLO[3,2-C]PYRIDINE is a highly reactive compound that requires careful handling and storage. It is important to follow safety protocols when working with this chemical to minimize the risk of exposure.

InChI:InChI=1/C7H5IN2/c8-6-4-10-7-1-2-9-3-5(6)7/h1-4,10H

Upstream product

• 271-34-1 5-azaindole 

Downstream Products

• 877060-48-5 tert-butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 877060-60-1 1-tert-butyloxycarbonyl-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrrolo[3,2-c]pyridine 
• 1316228-54-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-c]pyridine 
• 1316228-30-4 C₂₁H₂₁N₅O₂ 
• 1428226-68-9 C₁₇H₁₃N₅ 
• 1428226-74-7 C₁₇H₁₂ClN₅ 
• 1428226-75-8 C₁₇H₁₂ClN₅ 
• 1428226-76-9 C₁₇H₁₂ClN₅ 

Relevant articles and documents

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

N-substituted azaindoles as potent inhibitors of Cdc7 kinase

Cdc7 kinase is responsible for the initiation and regulation of DNA replication and has been proposed as a target for cancer therapy. We have identified a class of Cdc7 inhibitors based on a substituted indole core. Synthesis of focused indole and azaindole analogs yielded potent and selective 5-azaindole Cdc7 inhibitors with improved intrinsic metabolic stability (ie 36). In parallel, quantum mechanical conformational analysis helped to rationalize SAR observations, led to a proposal of the preferred binding conformation in the absence of co-crystallography data, and allowed the design of 7-azaindole 37 as a second lead in this series.

[4[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-(1H-PYRROLO-PYRIDIN-YL)-METHANONES AND SYNTHESIS THEREOF

The present invention relates herein to compounds and compositions for the treatment and amelioration of inflammatory disease. Specifically the present invention relates to compounds that having a tryptase inhibition activity and the intermediates thereof, pharmaceutical compositions comprising such compounds, and a method of treating subjects suffering from a condition disease or disorder that can be ameliorated by the administration of an inhibitor of tryptase including but not limited to for example asthma and other inflammatory diseases including age-related macular degeneration.