877140-79-9

Basic information

• Product Name: 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one
• Synonyms: 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one
• CAS NO: 877140-79-9
• Molecular Weight: 481.479
• Mol File: 877140-79-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one(877140-79-9)
• EPA Substance Registry System: 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one(877140-79-9)

Safety Data

• Hazardous Substances Data: 877140-79-9(Hazardous Substances Data)

Upstream product

• 749865-72-3 6-fluoro-1-(4-fluoro-benzyl)-1H-benzo[d][1,3]oxazine-2,4-dione 
• 877140-80-2 N-{3-[6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-7-yl}-acetamide 

Relevant articles and documents

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones

A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potenc