87732-55-6

Basic information

• Product Name: (S)-1-(3,4-Dihydro-8-methoxy-2-naphthyl)-2-(methoxymethyl)pyrrolidin
• Synonyms: (S)-1-(3,4-Dihydro-8-methoxy-2-naphthyl)-2-(methoxymethyl)pyrrolidin
• CAS NO: 87732-55-6
• Molecular Weight: 273.375
• Mol File: 87732-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(3,4-Dihydro-8-methoxy-2-naphthyl)-2-(methoxymethyl)pyrrolidin(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3,4-Dihydro-8-methoxy-2-naphthyl)-2-(methoxymethyl)pyrrolidin(87732-55-6)
• EPA Substance Registry System: (S)-1-(3,4-Dihydro-8-methoxy-2-naphthyl)-2-(methoxymethyl)pyrrolidin(87732-55-6)

Safety Data

• Hazardous Substances Data: 87732-55-6(Hazardous Substances Data)

Upstream product

• 5309-19-3 8-methoxy-2-tetralone 
• 63126-47-6 (2S)-2-(methoxymethyl)-1-pyrrolidine 

Downstream Products

• 87732-62-5 (3R,1'R)-3,4-Dihydro-8-methoxy-3-(2-nitro-1-phenylethyl)-2(1H)-naphthalinon 
• 87732-62-5 (-)-(3S,1'R)-3,4-Dihydro-8-methoxy-3-(2-nitro-1-phenylethyl)-2(1H)-naphthalinon 

Relevant articles and documents

Asymmetric Michael Additions. Regio-, Diastereo-, and Enantioselective Alkylations of the Enamines from β-Tetralones and (S)-2-(Methoxymethyl)pyrrolidine ("Prolinol Methyl Ether") by ω-Nitrostyrenes

β-Tetralones with various substituents (CH3, NO2, OCH3, OCH2O, Cl) in 1-, 5-, 6-, 7-, and 8-position are added to ω-nitrostyrenes (2) through enamines (1) derived from (S)-2-(methoxymethyl)pyrrolidine.Hydrolysis of the primary adducts (3) yields (35 - 55percent) β-tetralones 4 alkylated in the 3-position.These are all > 90percent diastereomerically and 75 - 99percent optically pure (see u-4 and Table 1).From results of earlier investigations it is inferred, that the present reaction occurs with relative topicity lk, ul-1,4 (see 6), i.e. that the products 4 have (3S,1'R)-configuration.This is compatible with the 1H NMR and CD spectra of the isolated products of type 4.