877614-86-3

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 877614-86-3
• Molecular Formula: C15H20ClNO2
• Molecular Weight: 281.782
• Mol File: 877614-86-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-, 1,1-dimethylethyl ester(877614-86-3)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 3-(4-chlorophenyl)-, 1,1-dimethylethyl ester(877614-86-3)

Safety Data

• Hazardous Substances Data: 877614-86-3(Hazardous Substances Data)

Upstream product

• 877614-85-2 benzyl 3-(4-chlorophenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 120418-62-4 3-(4-chlorophenyl)pyrrolidine 
• 1095545-18-8 3-(4-chlorophenyl)pyrrolidine hydrochloride 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 637-87-6 1-Chloro-4-iodobenzene 
• 73286-71-2 N-(tert-butoxycarbonyl)-2,3-dihydropyrrole 

Downstream Products

• 192514-97-9 tert-butyl 4-(4-chlorophenyl)-2-oxopyrrolidine-1-carboxylate 
• 70206-22-3 Baclofen hydrochloride 

Relevant articles and documents

Catalytic Strategy for Regioselective Arylethylamine Synthesis

A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small molecules.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

UREA DERIVATIVES AS ANTIBACTERIAL AGENTS

This invention relates to compounds of the Formula (I):or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC.