87770-02-3

Basic information

• Product Name: 4,4-dicarboxy-5-(p-methoxyphenyl)proline
• CAS NO: 87770-02-3
• Molecular Weight: 309.276
• Mol File: 87770-02-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4-dicarboxy-5-(p-methoxyphenyl)proline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dicarboxy-5-(p-methoxyphenyl)proline(87770-02-3)
• EPA Substance Registry System: 4,4-dicarboxy-5-(p-methoxyphenyl)proline(87770-02-3)

Safety Data

• Hazardous Substances Data: 87770-02-3(Hazardous Substances Data)

Upstream product

• 56271-99-9 2-amino-4-carboxypentanedioic acid 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Reaction of γ-carboxyglutamic acid with aldehydes

The DL-γ-carboxyglutamic acid (Gla) reacts quantitatively with formaldehyde to give 4,4-dicarboxyproline and with other aldehydes to give the racemic diastereoisomers of the 5-substituted 4,4-dicarboxyprolines.The pH-dependent reaction rate and the stereochemical behaviour suggest an intramolecular Manich mechanism. After heating at 100 deg C for 30 min, the 4,4-dicarboxyproline and the 5-substituted 4,4-dicarboxyprolines lose a carboxyl group from C4 to give the racemic diastereoisomers of the cyclic analogs of glutamic acid.