87781-99-5Relevant articles and documents
N2 (phenyl substituted) deoxy guanosine containing compounds
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, (2008/06/13)
New purine compounds having the formula: STR1 Y and Y'=H, STR2 X=H, alkyl, halo; STR3 A=O, S, NH2 are provided. These compounds are useful in treating patients having cancer, since they are potent and selective inhibitors of replicative DNA synthesis in mammalian cells since they inhibit DNA polymerase α. New purine compounds also are provided having the formula: STR4 wherein Y, A, Z are as defined above, X'=C2 H5 Y"=--CH3 or STR5 These compounds are useful to prevent bacterial growth since they are potent inhibitors of DNA polymerase III. New Purine compounds also are provided having the formula: STR6 wherein Z' is H, OH or CH2 OH, A' is O of CH2 X"=H, alkyl, halo E=n-butyl, alkyl, halo, H G= STR7